Sugi Predict

Sugi Predict / Compounds / SCHEMBL10237145

SCHEMBL10237145

SCHEMBL10237145

OC[C@H]1COCCc2nc3cnc4ccccc4c3n21

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ GLA P06280 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ LRRK2 Q5S007 8/20 0.32
▸ JAK1 P23458 6/20 0.32
▸ JAK2 O60674 4/20 0.32
▸ JAK3 P52333 3/20 0.32
▸ TYK2 P29597 1/20 0.32
▸ TLR7 Q9NYK1 1/20 0.31
▸ MTOR P42345 2/20 0.31
▸ GPR3 P46089 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12020770 0.89 KDM4E (0.33) KDM4EALDH1A1GLAGAAHPGD
SCHEMBL12201431 0.89 KDM4E (0.33) KDM4EALDH1A1GLAGAAHPGD
SCHEMBL1774432 0.88 ABL1 (0.37) KDM4EALDH1A1GLAGAAHPGD
SCHEMBL12020703 0.87 TLR7 (0.35) KDM4EALDH1A1GLAGAAHPGD
SCHEMBL12201376 0.87 TLR7 (0.35) KDM4EALDH1A1GLAGAAHPGD
SCHEMBL10237144 0.82 TAAR1 (0.33) KDM4ELRRK2TLR7
SCHEMBL10237143 0.80 TLR7 (0.46) TLR7
SCHEMBL12020838 0.79 ACACB (0.41) JAK1JAK2JAK3TYK2
SCHEMBL12201398 0.79 ACACB (0.41) JAK1JAK2JAK3TYK2
SCHEMBL1775336 0.74 GRM5 (0.41) KDM4EALDH1A1GLAGAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8546383-B2 Chiral fused [1,2]imidazo[4,5-c] ring compounds 3M INNOVATIVE PROPERTIES COMPANY (US) 2013-10-01 — — US disclosed
US-20120232057-A1 CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS 3M INNOVATIVE PROPERTIES COMPANY 2012-09-13 — — US disclosed
US-8207162-B2 Chiral fused [1,2]imidazo[4,5-c] ring compounds 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-06-26 — — US disclosed
US-20110207725-A1 CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS 3M INNOVATIVE PROPERTIES COMPANY 2011-08-25 — — US disclosed
US-7943609-B2 Such as (tetrahydr)imidazo(4,5-c ) quinoline or naphthymidine; immunomoderators; induce cytokine biosynthesis in animals; anticancer agents; viricides 3M INNOVATIVE PROPRERTIES COMPANY (US) 2011-05-17 — — US disclosed
US-20080269192-A1 Chiral Fused [1,2]Imidazo[4,5-C] Ring Compounds COLEY PHARMACEUTICAL GROUP, INC. (US) 2008-10-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080269192-A1 Chiral Fused [1,2]Imidazo[4,5-C] Ring Compounds IFNAR1, IFNG, IL4 KDM4E 3100/4885ALDH1A1 1323/4885GLA 3837/4885
US-20120232057-A1 CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS IFNAR1, IFNG, IL4 KDM4E 3075/4885ALDH1A1 1278/4885GLA 3842/4885
US-20110207725-A1 CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS IFNAR1, IFNG, IL4 KDM4E 3100/4885ALDH1A1 1323/4885GLA 3837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.