Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19006734 | 1.00 | POLB (0.52) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL13360488 | 0.98 | POLB (0.48) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL14278538 | 0.91 | ATM (0.46) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL947830 | 0.78 | POLB (0.46) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL13360504 | 0.76 | POLB (0.44) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL11193250 | 0.76 | SMN1; SMN2 (0.51) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL23890951 | 0.75 | POLB (0.43) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL6493190 | 0.73 | SMN1; SMN2 (0.49) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL12414740 | 0.73 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL3951994 | 0.73 | POLB (0.42) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082997-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA-ROCHE AG (CH) | 2012-06-21 | — | — | WO | disclosed |