Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.36 |
| ▸ | PDE1A | P54750 | 3/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.33 |
| ▸ | CDK2 | P24941 | 5/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595888 | 0.96 | NTRK1 (0.36) | METNTRK1PDE3BPDE3AMEN1 | |
| SCHEMBL7882869 | 0.95 | KCNH2 (0.38) | METPDE1BPDE1CPDE1ANTRK1 | |
| SCHEMBL7879911 | 0.94 | KMT2A (0.35) | METNTRK1MEN1NPC1RAB9A | |
| SCHEMBL10235234 | 0.92 | PDE1B (0.36) | METPDE1BPDE1CPDE1APDE3B | |
| SCHEMBL10235011 | 0.88 | HSP90AA1 (0.34) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL10235263 | 0.88 | OPRK1 (0.36) | PDE1BPDE1CPDE1AMEN1NPC1 | |
| SCHEMBL10239336 | 0.87 | GAA (0.35) | MEN1NPC1RAB9AKMT2AMAPK14 | |
| SCHEMBL10235231 | 0.86 | CHEK1 (0.34) | MEN1NPC1RAB9AKMT2ACHEK1 | |
| SCHEMBL10239329 | 0.86 | OPRK1 (0.35) | METNTRK1MEN1NPC1RAB9A | |
| SCHEMBL7874925 | 0.85 | DYRK1A (0.37) | METMAPK14JAK2CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MET 1965/4885PDE1B 3452/4885PDE1C 4273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.