Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.34 |
| ▸ | CDK2 | P24941 | 9/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239331 | 0.94 | MET (0.37) | KMT2ARAB9AMEN1NPC1CHEK1 | |
| SCHEMBL7882869 | 0.93 | KCNH2 (0.38) | KMT2ARAB9AMEN1NPC1CHEK1 | |
| SCHEMBL595888 | 0.92 | NTRK1 (0.36) | KMT2ARAB9AMEN1NPC1CHEK1 | |
| SCHEMBL10235231 | 0.92 | CHEK1 (0.34) | KMT2ARAB9AMEN1NPC1CHEK1 | |
| SCHEMBL10239336 | 0.87 | GAA (0.35) | KMT2ARAB9AMEN1NPC1CHEK1 | |
| SCHEMBL10235234 | 0.86 | PDE1B (0.36) | CHEK1CCNA2CDK2CCNA1MET | |
| SCHEMBL7874925 | 0.86 | DYRK1A (0.37) | CCNA2CDK2METMAP4K4 | |
| SCHEMBL10239339 | 0.86 | GAA (0.38) | KMT2ARAB9AMEN1NPC1CHEK1 | |
| SCHEMBL10235263 | 0.85 | OPRK1 (0.36) | KMT2ARAB9AMEN1NPC1CHEK1 | |
| SCHEMBL7884571 | 0.84 | GAA (0.35) | KMT2ARAB9AMEN1NPC1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | KMT2A 2825/4885RAB9A 720/4885MEN1 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.