Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 4/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | ITK | Q08881 | 2/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.31 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028573 | 0.93 | STK17B (0.39) | P2RX3SYKEGFRSTK17BSTK17A | |
| SCHEMBL1027538 | 0.92 | SYK (0.41) | P2RX3SYKEGFRITKSTK17B | |
| SCHEMBL1024066 | 0.91 | EGFR (0.37) | P2RX3SYKEGFRITKSTK17B | |
| SCHEMBL1024947 | 0.88 | P2RX3 (0.37) | P2RX3SYKEGFRITKSTK17B | |
| SCHEMBL13623074 | 0.88 | P2RX3 (0.38) | P2RX3SYKEGFRITKSTK17B | |
| SCHEMBL1025607 | 0.84 | STK17B (0.39) | P2RX3SYKEGFRSTK17BSTK17A | |
| SCHEMBL2523025 | 0.84 | STK17B (0.42) | STK17BSTK17AKCNQ4KCNQ5JAK3 | |
| SCHEMBL1027536 | 0.83 | SYK (0.44) | P2RX3SYKEGFRITKCDK1 | |
| SCHEMBL4340593 | 0.82 | STK17B (0.41) | P2RX3SYKEGFRSTK17BSTK17A | |
| SCHEMBL4338777 | 0.82 | EGFR (0.42) | P2RX3SYKEGFRITKCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |