Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 3/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023940 | 0.93 | P2RX3 (0.35) | STK17BSTK17AP2RX3SYKCDK1 | |
| SCHEMBL1027538 | 0.93 | SYK (0.41) | STK17BSTK17AP2RX3SYKCDK1 | |
| SCHEMBL1025607 | 0.91 | STK17B (0.39) | STK17BSTK17ABCL6P2RX3SYK | |
| SCHEMBL2523025 | 0.89 | STK17B (0.42) | STK17BSTK17AMAPK3 | |
| SCHEMBL13622748 | 0.88 | STK17B (0.43) | STK17BSTK17ABCL6P2RX3SYK | |
| SCHEMBL4340593 | 0.88 | STK17B (0.41) | STK17BSTK17ABCL6P2RX3SYK | |
| SCHEMBL1024066 | 0.84 | EGFR (0.37) | STK17BSTK17AP2RX3SYKCDK1 | |
| SCHEMBL1027536 | 0.84 | SYK (0.44) | P2RX3SYKMETCDK1EGFR | |
| SCHEMBL13622745 | 0.82 | SYK (0.43) | STK17BSTK17ABCL6SYKMET | |
| SCHEMBL1024947 | 0.81 | P2RX3 (0.37) | STK17BSTK17AP2RX3SYKCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |