Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KIF5B | P33176 | 1/20 | 0.37 |
| ▸ | ETV6 | P41212 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | HCK | P08631 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894469 | 0.90 | CHEK1 (0.47) | METPIK3CAKDRRETKIF5B | |
| SCHEMBL6891401 | 0.85 | CHEK1 (0.43) | METPIK3CAKDRRETKIF5B | |
| SCHEMBL10235015 | 0.82 | CHEK1 (0.46) | PIK3CARETCHEK1CCNA2CDK2 | |
| SCHEMBL10234596 | 0.81 | CHEK1 (0.44) | PIK3CARETCHEK1CCNA2CDK2 | |
| SCHEMBL7883101 | 0.81 | PIK3CA (0.38) | METPIK3CAKDRCHEK1CCNA2 | |
| SCHEMBL6893583 | 0.81 | CHEK1 (0.45) | PIK3CARETCHEK1CCNA2CDK2 | |
| SCHEMBL7882530 | 0.80 | CHEK1 (0.50) | RETCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7874758 | 0.80 | DGAT1 (0.41) | PIK3CAKCNH2CHEK1CCNA2CDK2 | |
| SCHEMBL2680149 | 0.80 | CHEK1 (0.44) | METPIK3CARETCHEK1CCNA2 | |
| SCHEMBL6891852 | 0.80 | CHEK1 (0.45) | METPIK3CACHEK1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MET 1965/4885PIK3CA 34/4885KDR 3315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.