Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.37 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 8/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 6/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240078 | 0.91 | MTOR (0.43) | RAB9ANPC1KDM4EALDH1A1HPGD | |
| SCHEMBL10240027 | 0.91 | MTOR (0.35) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10240089 | 0.89 | MTOR (0.36) | SMN1; SMN2MTORRPTORMLST8PIK3CA | |
| SCHEMBL7881551 | 0.89 | CHEK1 (0.42) | MTORRPTORMLST8TYRO3PIK3CA | |
| SCHEMBL10234815 | 0.89 | CHEK1 (0.44) | RAB9ANPC1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL10240025 | 0.89 | CHEK1 (0.41) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10240086 | 0.88 | NPC1 (0.37) | RAB9ANPC1MTORRPTORMLST8 | |
| SCHEMBL10234867 | 0.88 | RAB9A (0.38) | RAB9ANPC1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL10240075 | 0.88 | MTOR (0.35) | MTORRPTORMLST8PIK3CAPIK3CD | |
| SCHEMBL10240148 | 0.87 | MTOR (0.33) | MTORRPTORMLST8PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | RAB9A 720/4885NPC1 348/4885KDM4E 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.