Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.32 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240028 | 0.92 | MTOR (0.35) | MTORRPTORMLST8TP53PIK3CA | |
| SCHEMBL10240026 | 0.91 | RAB9A (0.37) | MTORRPTORMLST8PIK3CAPIK3CD | |
| SCHEMBL10240078 | 0.89 | MTOR (0.43) | MTORRPTORMLST8PIK3CAPIK3CD | |
| SCHEMBL10234896 | 0.89 | THRB (0.36) | MTORRPTORMLST8THRBTP53 | |
| SCHEMBL10240089 | 0.88 | MTOR (0.36) | MTORRPTORMLST8PIK3CAPIK3CD | |
| SCHEMBL7881551 | 0.88 | CHEK1 (0.42) | MTORRPTORMLST8PIK3CAPIK3CD | |
| SCHEMBL10240025 | 0.87 | CHEK1 (0.41) | MTORRPTORMLST8PIK3CAPIK3CD | |
| SCHEMBL10240086 | 0.87 | NPC1 (0.37) | MTORRPTORMLST8PIK3CAPIK3CD | |
| SCHEMBL10240075 | 0.86 | MTOR (0.35) | MTORRPTORMLST8PIK3CAPIK3CD | |
| SCHEMBL10240054 | 0.86 | CHEK1 (0.34) | MTORRPTORMLST8PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MTOR 1/4885RPTOR 3/4885MLST8 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.