⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclooctane SCHEMBL2204516 | 1.00 | TSHR (0.50) | — | |
| Cyclohexane SCHEMBL3191478 | 1.00 | TSHR (0.50) | — | |
| Cyclopentane SCHEMBL959166 | 1.00 | — | — | |
| Cyclohexane SCHEMBL254050 | 1.00 | — | — | |
| Methyl Alcohol SCHEMBL7653457 | 1.00 | TSHR (0.50) | — | |
| Methyl Alcohol SCHEMBL1581201 | 1.00 | — | — | |
| Cycloheptane SCHEMBL2652378 | 1.00 | — | — | |
| Cyclohexane SCHEMBL9165359 | 1.00 | TSHR (0.50) | — | |
| Methyl Alcohol SCHEMBL1223378 | 1.00 | TSHR (0.50) | — | |
| Cyclohexane SCHEMBL9632064 | 1.00 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 270 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250263419-A1 | Preparation of Buprenorphine | RIVER STONE BIOTECH APS (DK) | 2025-08-21 | — | — | US | claimed |
| EP-4090662-B1 | PREPARATION OF BUPRENORPHINE | RIVER STONE BIOTECH APS (DK) | 2024-06-12 | — | — | EP | claimed |
| US-20240150804-A1 | Demethylation of Reticuline and Derivatives Thereof with Fungal Cytochrome P450 | RIVER STONE BIOTECH, INC. | 2024-05-09 | — | — | US | claimed |
| US-20230332195-A1 | GENETICALLY MODIFIED HOST CELLS PRODUCING BENZYLISOQUINOLINE ALKALOIDS | RIVER STONE BIOTECH APS (DK) | 2023-10-19 | — | — | US | claimed |
| CN-115873388-A | Hydrophobic high-bamboo-powder-filled biodegradable composite material and preparation method thereof | 中广核高新核材科技（苏州）有限公司 | 2023-03-31 | — | — | CN | claimed |
| EP-4041891-A1 | GENETICALLY MODIFIED HOST CELLS PRODUCING BENZYLISOQUINOLINE ALKALOIDS | River Stone Biotech ApS (DK) | 2022-08-17 | — | — | EP | claimed |
| US-11390628-B2 | Preparation of buprenorphine | RIVER STONE BIOTECH LLC (US) | 2022-07-19 | — | — | US | claimed |
| US-20210380597-A1 | PREPARATION OF BUPRENORPHINE | River Stone Biotech Inc. | 2021-12-09 | — | — | US | claimed |
| WO-2021144362-A1 | PREPARATION OF BUPRENORPHINE | RIVER STONE BIOTECH APS (DK) | 2021-07-22 | — | — | WO | claimed |
| CN-113087673-A | Preparation method of alkyl/alkenyl substituted nitrogen-containing heterocyclic compound | 河南农业大学 | 2021-07-09 | — | — | CN | claimed |
| WO-2021069714-A1 | GENETICALLY MODIFIED HOST CELLS PRODUCING BENZYLISOQUINOLINE ALKALOIDS | RIVER STONE BIOTECH APS (DK) | 2021-04-15 | — | — | WO | claimed |
| EP-3638791-A1 | DEMETHYLATION OF RETICULINE AND DERIVATIVES THEREOF WITH FUNGAL CYTOCHROME P450 | River Stone Biotech APS (DK) | 2020-04-22 | — | — | EP | claimed |
| EP-3625235-A1 | PREPARATION OF BUPRENORPHINE | River Stone Biotech, LLC (US) | 2020-03-25 | — | — | EP | claimed |
| WO-2018229306-A9 | DEMETHYLATION OF RETICULINE AND DERIVATIVES THEREOF WITH FUNGAL CYTOCHROME P450 | RIVER STONE BIOTECH APS (DK) | 2019-02-21 | — | — | WO | claimed |
| WO-2018229306-A1 | DEMETHYLATION OF RETICULINE AND DERIVATIVES THEREOF WITH FUNGAL CYTOCHROME P450 | RIVER STONE BIOTECH APS (DK) | 2018-12-20 | — | — | WO | claimed |
| WO-2018211331-A1 | PREPARATION OF BUPRENORPHINE | EVOLVA SA (CH) | 2018-11-22 | — | — | WO | claimed |
| US-20250263419-A1 | Preparation of Buprenorphine | RIVER STONE BIOTECH APS (DK) | 2025-08-21 | — | — | US | disclosed |
| US-12227515-B2 | In-flow photooxygenation of aminothienopyridinones generates novel PTP4A3 phosphatase inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2025-02-18 | — | — | US | disclosed |
| EP-0376114-A2 | 9-Dihydro-9-0-alkyldesmycosin derivatives | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1990-07-04 | — | — | EP | disclosed |
| CN-85106878-A | The method for preparing compound | — | 1986-07-23 | — | — | CN | disclosed |