Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.38 |
| ▸ | TUBB | P07437 | 5/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10241734 | 1.00 | AAK1 (0.40) | AAK1LMNARXFP1TUBB4ATUBB | |
| Hydrochloric Acid SCHEMBL623120 | 0.99 | AAK1 (0.39) | AAK1LMNARXFP1TUBB4ATUBB | |
| SCHEMBL10240635 | 0.94 | LMNA (0.41) | AAK1LMNARXFP1TUBB4ATUBB | |
| SCHEMBL10240310 | 0.94 | LMNA (0.41) | AAK1LMNARXFP1TUBB4ATUBB | |
| Hydrochloric Acid SCHEMBL625513 | 0.93 | LMNA (0.41) | AAK1LMNARXFP1TUBB4ATUBB | |
| SCHEMBL616321 | 0.92 | LMNA (0.40) | AAK1LMNARXFP1TUBB4ATUBB | |
| Hydrochloric Acid SCHEMBL618987 | 0.91 | LMNA (0.40) | AAK1LMNARXFP1TUBB4ATUBB | |
| SCHEMBL10241271 | 0.91 | AAK1 (0.43) | AAK1LMNARXFP1TUBB4ATUBB | |
| SCHEMBL10241708 | 0.91 | AAK1 (0.43) | AAK1LMNARXFP1TUBB4ATUBB | |
| Hydrochloric Acid SCHEMBL623340 | 0.90 | AAK1 (0.43) | AAK1LMNARXFP1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130203824-A1 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | SUN LIJUN (US) | 2013-08-08 | — | — | US | disclosed |
| US-8399435-B2 | Compounds for the treatment of proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120040937-A1 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. | 2012-02-16 | — | — | US | disclosed |
| US-8058297-B2 | Compounds for the treatment of proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-15 | — | — | US | disclosed |
| US-8058297-B2 | Compounds for the treatment of proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20090270353-A1 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | SUN LIJUN | 2009-10-29 | — | — | US | disclosed |
| US-20090270353-A1 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | SUN LIJUN | 2009-10-29 | — | — | US | disclosed |
| US-7572821-B2 | Compounds for the treatment of proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572821-B2 | Compounds for the treatment of proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-11 | — | — | US | disclosed |
| US-20070179159-A1 | Compounds for the treatment of proliferative disorders | SYNTA PHARMACEUTICALS CORP. | 2007-08-02 | — | — | US | disclosed |
| US-20070179159-A1 | Compounds for the treatment of proliferative disorders | SYNTA PHARMACEUTICALS CORP. | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179159-A1 | Compounds for the treatment of proliferative disorders | RB1, MKI67, MAPRE1 | AAK1 3020/4885LMNA 2274/4885RXFP1 847/4885 |
| US-20120040937-A1 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | RB1, MKI67, MAPRE1 | AAK1 3020/4885LMNA 2274/4885RXFP1 847/4885 |
| US-20090270353-A1 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | RB1, MKI67, MAPRE1 | AAK1 3020/4885LMNA 2274/4885RXFP1 847/4885 |
| US-20130203824-A1 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | RB1, MKI67, MAPRE1 | AAK1 3020/4885LMNA 2274/4885RXFP1 847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.