SCHEMBL10240992

SCHEMBL10240992

Nc1ccc2c(c1)C(=O)N(c1ccc(Nc3ccccc3)cc1)C2=O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.67
KMT2A Q03164 3/20 0.67
GFER P55789 2/20 0.67
ALDH1A1 P00352 5/20 0.63
RAB9A P51151 3/20 0.63
NPC1 O15118 2/20 0.63
TSHR P16473 2/20 0.63
CASP1 P29466 2/20 0.63
CASP7 P55210 1/20 0.63
HSD17B10 Q99714 1/20 0.63
MAPK1 P28482 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
APP P05067 1/20 0.54
HSP90AA1 P07900 1/20 0.51
ANPEP P15144 2/20 0.49
ESR1 P03372 2/20 0.49
DPP4 P27487 1/20 0.49
MAPT P10636 3/20 0.49
CYP3A4 P08684 2/20 0.49
CYP1A2 P05177 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4782142 0.86 ALDH1A1 (0.72) MEN1KMT2AALDH1A1RAB9ANPC1
SCHEMBL2132967 0.84 KMT2A (0.68) MEN1KMT2AGFERALDH1A1RAB9A
SCHEMBL8995319 0.84 CASP1 (0.86) MEN1KMT2AALDH1A1RAB9ANPC1
SCHEMBL26756421 0.84 ALDH1A1 (0.56) MEN1KMT2AGFERALDH1A1RAB9A
SCHEMBL9566650 0.82 CASP1 (0.83) MEN1KMT2AALDH1A1RAB9ANPC1
SCHEMBL23775707 0.81 MEN1 (0.81) MEN1KMT2AGFERALDH1A1RAB9A
SCHEMBL23775711 0.81 SCN2A (0.64) MEN1KMT2AGFERRAB9ANPSR1
SCHEMBL10189837 0.80 KMT2A (1.00) MEN1KMT2AGFERALDH1A1RAB9A
SCHEMBL15841150 0.80 MEN1 (0.64) MEN1KMT2AGFERALDH1A1RAB9A
SCHEMBL4547161 0.80 MEN1 (0.64) MEN1KMT2AGFERALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2450348-A1 NOVEL DIARYLAMINE COMPOUND, AND ANTI-AGING AGENT, POLYMER COMPOSITION, CROSSLINKED RUBBER PRODUCT AND MOLDED ARTICLE THEREOF, AND METHOD FOR PRODUCING DIARYLAMINE COMPOUND Zeon Corporation (JP) 2012-05-09 EP disclosed