Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 6/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362814 | 1.00 | GPBAR1 (0.67) | GPBAR1FFAR1NR3C2CTSAFFAR4 | |
| SCHEMBL362813 | 1.00 | GPBAR1 (0.67) | GPBAR1FFAR1NR3C2CTSAFFAR4 | |
| SCHEMBL363911 | 0.89 | GPBAR1 (0.52) | GPBAR1FFAR1NR3C2CTSAFFAR4 | |
| SCHEMBL1389611 | 0.88 | GPBAR1 (0.67) | GPBAR1FFAR1NR3C2CTSA | |
| SCHEMBL10240980 | 0.88 | GPBAR1 (0.67) | GPBAR1FFAR1NR3C2CTSA | |
| SCHEMBL1389609 | 0.88 | GPBAR1 (0.67) | GPBAR1FFAR1NR3C2CTSA | |
| SCHEMBL10280514 | 0.84 | GPBAR1 (0.73) | GPBAR1FFAR1NR3C2CTSAFFAR4 | |
| SCHEMBL368289 | 0.83 | GPBAR1 (0.71) | GPBAR1NR3C2CTSA | |
| SCHEMBL364229 | 0.83 | GPBAR1 (0.71) | GPBAR1NR3C2CTSA | |
| SCHEMBL368291 | 0.83 | GPBAR1 (0.71) | GPBAR1NR3C2CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885FFAR1 14/4885NR3C2 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.