Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10242120 | 0.98 | MAPT (0.32) | — | |
| SCHEMBL11684385 | 0.74 | ALDH1A1 (0.33) | — | |
| SCHEMBL10110368 | 0.66 | — | — | |
| SCHEMBL22313102 | 0.66 | — | — | |
| SCHEMBL4026362 | 0.66 | — | — | |
| SCHEMBL14231549 | 0.66 | — | — | |
| SCHEMBL16438955 | 0.65 | KMT2A (0.34) | CA1CA2CA4CA9 | |
| SCHEMBL22559981 | 0.65 | LMNA (0.37) | CA1CA2CA4 | |
| SCHEMBL20794170 | 0.63 | CHRM2 (0.30) | — | |
| SCHEMBL15743938 | 0.63 | CHRM2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765793-B1 | ANACETRAPIB AND OTHER CETP INHIBITPRS | MERCK SHARP & DOHME (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |