Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 4/20 | 0.40 |
| ▸ | MET | P08581 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371554 | 0.92 | FGFR2 (0.48) | FGFR2PDGFRAPDGFRBAXLKDR | |
| SCHEMBL20525612 | 0.80 | ILK (0.38) | FGFR2 | |
| SCHEMBL4575949 | 0.79 | AXL (0.57) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL4591188 | 0.79 | FGFR2 (0.51) | FGFR2PDGFRAPDGFRBSRCTGFBR1 | |
| Bromide SCHEMBL15918462 | 0.78 | AXL (0.56) | FGFR2PDGFRAPDGFRBAXLMET | |
| SCHEMBL5707550 | 0.78 | CYP3A4 (0.53) | AXL | |
| SCHEMBL24444554 | 0.77 | MET (0.43) | PDGFRAPDGFRBAXLMETKDR | |
| Hydrochloric Acid SCHEMBL5707606 | 0.77 | CYP3A4 (0.51) | AXL | |
| SCHEMBL24444616 | 0.76 | MET (0.58) | PDGFRAPDGFRBAXLMETKDR | |
| SCHEMBL13787639 | 0.76 | SRC (0.61) | FGFR2PDGFRAPDGFRBAXLMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2392565-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2392564-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |