Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL27687949 | 0.98 | USP2 (0.51) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL2223926 | 0.85 | USP2 (0.53) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL8671452 | 0.85 | HPGD (0.43) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL698803 | 0.84 | USP2 (0.69) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL18294 | 0.84 | USP2 (0.69) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL11339897 | 0.81 | USP2 (0.56) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL27476553 | 0.81 | USP2 (0.49) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL1484362 | 0.80 | USP2 (0.60) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL28880962 | 0.79 | USP2 (0.50) | USP2SMN1; SMN2HPGDRECQLEPHX2 | |
| SCHEMBL16357990 | 0.79 | USP2 (0.58) | USP2SMN1; SMN2HPGDRECQLEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |
| CN-101124203-A | Chemical compounds | ASTRAZENECA AB (SE) | 2008-02-13 | — | — | CN | disclosed |