Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LONP1 | P36776 | 3/20 | 0.40 |
| ▸ | CLPP | Q16740 | 7/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 10/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15291281 | 0.93 | LONP1 (0.40) | LONP1CLPPPSMB5 | |
| SCHEMBL3174660 | 0.93 | LONP1 (0.40) | LONP1CLPPPSMB5 | |
| SCHEMBL15628855 | 0.90 | LONP1 (0.42) | LONP1CLPPPSMB5 | |
| SCHEMBL608029 | 0.78 | CTSV (0.37) | — | |
| SCHEMBL12829268 | 0.78 | PSMB5 (0.46) | LONP1CLPPPSMB5 | |
| SCHEMBL12829159 | 0.78 | PSMB5 (0.43) | LONP1PSMB5 | |
| SCHEMBL12829155 | 0.76 | PSMB5 (0.52) | LONP1PSMB5 | |
| SCHEMBL608028 | 0.76 | CTSV (0.33) | — | |
| SCHEMBL12754441 | 0.76 | CLPP (0.42) | LONP1CLPPPSMB5 | |
| SCHEMBL12829270 | 0.74 | PSMB5 (0.38) | LONP1CLPPPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041196-A1 | Proteasome Inhibitors and Methods of Using the Same | CEPHALON, INC. (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041196-A1 | Proteasome Inhibitors and Methods of Using the Same | PSMB11, PSMB5, PSMB6 | LONP1 279/4885CLPP 180/4885PSMB5 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.