Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 4/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | CPS1 | P31327 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17350911 | 1.00 | ESR1 (0.49) | ESR1GHSRSLC18A3SIGMAR1KDM4E | |
| SCHEMBL17350595 | 0.92 | NPC1 (0.48) | ESR1GHSRSLC18A3SIGMAR1POLB | |
| SCHEMBL10243905 | 0.92 | NPC1 (0.48) | ESR1GHSRSLC18A3SIGMAR1POLB | |
| SCHEMBL17350984 | 0.83 | POLB (0.57) | SLC18A3SIGMAR1KDM4EALDH1A1POLB | |
| SCHEMBL10243883 | 0.83 | POLB (0.57) | SLC18A3SIGMAR1KDM4EALDH1A1POLB | |
| SCHEMBL17350905 | 0.81 | HSD11B1 (0.51) | SLC18A3SIGMAR1KDM4EALDH1A1POLB | |
| SCHEMBL10243989 | 0.81 | HSD11B1 (0.51) | SLC18A3SIGMAR1KDM4EALDH1A1POLB | |
| SCHEMBL17350840 | 0.80 | HSP90AA1 (0.47) | SLC18A3SIGMAR1ALDH1A1HPGDPOLB | |
| SCHEMBL10243810 | 0.80 | HSP90AA1 (0.47) | SLC18A3SIGMAR1ALDH1A1HPGDPOLB | |
| SCHEMBL17350637 | 0.79 | HSD11B1 (0.42) | SLC18A3SIGMAR1POLBKDM1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115853-A1 | Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | HSD11B1, HSD11B2, HSD17B1 | ESR1 2982/4885GHSR 542/4885SLC18A3 3630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.