Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 14/20 | 0.53 |
| ▸ | AXL | P30530 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19372993 | 0.88 | FGFR2 (0.62) | FGFR2PDGFRAMETAXLKDR | |
| SCHEMBL22521192 | 0.85 | FGFR2 (0.59) | FGFR2PDGFRAMETAXLKDR | |
| SCHEMBL374061 | 0.84 | PDGFRA (0.63) | FGFR2PDGFRAMETAXLKDR | |
| SCHEMBL20216881 | 0.84 | FGFR2 (0.60) | FGFR2PDGFRAMETAXLKDR | |
| SCHEMBL2573722 | 0.82 | FGFR2 (0.67) | FGFR2PDGFRAMETAXLKDR | |
| SCHEMBL13787639 | 0.82 | SRC (0.61) | FGFR2PDGFRAMETAXLKDR | |
| SCHEMBL4575949 | 0.81 | AXL (0.57) | FGFR2PDGFRAMETAXLKDR | |
| SCHEMBL12335711 | 0.81 | MET (0.67) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL373942 | 0.80 | FGFR2 (0.59) | FGFR2PDGFRAMETAXLKDR | |
| Bromide SCHEMBL15918462 | 0.80 | AXL (0.56) | FGFR2PDGFRAMETAXLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2213661-A1 | c-Met Modulators and Methods of Use | Exelixis Inc. (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-2210607-A1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-piperidin-1-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | Exelixis Inc. (US) | 2010-07-28 | — | — | EP | disclosed |