Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.67 |
| ▸ | AXL | P30530 | 7/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 13/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049533 | 0.87 | FGFR2 (0.71) | FGFR2AXLPDGFRAMETKDR | |
| SCHEMBL22407381 | 0.85 | FGFR2 (0.66) | FGFR2AXLPDGFRAMETKDR | |
| SCHEMBL13210987 | 0.85 | MET (0.64) | FGFR2AXLMETKDR | |
| SCHEMBL23617110 | 0.84 | FGFR2 (0.67) | FGFR2AXLPDGFRAMETKDR | |
| SCHEMBL29822421 | 0.84 | FGFR2 (0.67) | FGFR2AXLPDGFRAMETKDR | |
| SCHEMBL25533184 | 0.83 | AXL (0.49) | FGFR2AXLPDGFRAMETKDR | |
| SCHEMBL5825531 | 0.83 | FGFR2 (0.73) | FGFR2AXLPDGFRAKDR | |
| SCHEMBL10243948 | 0.82 | FGFR2 (0.59) | FGFR2AXLPDGFRAMETKDR | |
| SCHEMBL371919 | 0.82 | PDGFRA (0.66) | AXLPDGFRAMETKDRFLT3 | |
| SCHEMBL5056203 | 0.82 | PDGFRA (0.72) | FGFR2AXLPDGFRAMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673085-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2011-11-09 | — | — | EP | disclosed |