Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693400 | 0.77 | ALDH1A1 (0.53) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL371986 | 0.76 | ALDH1A1 (0.44) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL4401208 | 0.76 | ALDH1A1 (0.44) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL10254974 | 0.72 | POLB (0.45) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL19372979 | 0.72 | ALDH1A1 (0.44) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL13271303 | 0.72 | ALDH1A1 (0.44) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL18530076 | 0.71 | ALDH1A1 (0.52) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL19373095 | 0.71 | GAA (0.45) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL19373187 | 0.71 | ALDH1A1 (0.50) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL29693415 | 0.71 | ALDH1A1 (0.50) | ALDH1A1GAAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2213661-A1 | c-Met Modulators and Methods of Use | Exelixis Inc. (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-2210607-A1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-piperidin-1-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | Exelixis Inc. (US) | 2010-07-28 | — | — | EP | disclosed |