Sugi Predict

Sugi Predict / Compounds / SCHEMBL4401208

SCHEMBL4401208

SCHEMBL4401208

C[C@@H]1C[C@@]1(C(=O)O)C(=O)Nc1ccc(F)cc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.44
▸ FAAH O00519 1/20 0.43
▸ NPC1 O15118 3/20 0.42
▸ RAB9A P51151 3/20 0.42
▸ GAA P10253 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ P2RX7 Q99572 1/20 0.42
▸ POLB P06746 2/20 0.41
▸ ENPP3 O14638 1/20 0.41
▸ CA12 O43570 1/20 0.41
▸ ENPP1 P22413 1/20 0.41
▸ ENPP2 Q13822 1/20 0.41
▸ CA9 Q16790 1/20 0.41
▸ MITF O75030 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ GRIN2B Q13224 1/20 0.41
▸ MAOB P27338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL371986 1.00 ALDH1A1 (0.44) ALDH1A1FAAHNPC1RAB9AGAA
SCHEMBL10254974 0.88 POLB (0.45) ALDH1A1NPC1RAB9AGAASMN1; SMN2
SCHEMBL19373187 0.86 ALDH1A1 (0.50) ALDH1A1NPC1RAB9AGAASMN1; SMN2
SCHEMBL29693415 0.86 ALDH1A1 (0.50) ALDH1A1NPC1RAB9AGAASMN1; SMN2
SCHEMBL15862314 0.85 SLC6A2 (0.47) ALDH1A1FAAHNPC1RAB9AGAA
SCHEMBL4403222 0.85 ALDH1A1 (0.45) ALDH1A1FAAHNPC1RAB9AGAA
SCHEMBL19372979 0.78 ALDH1A1 (0.44) ALDH1A1NPC1RAB9AGAASMN1; SMN2
SCHEMBL13271303 0.78 ALDH1A1 (0.44) ALDH1A1NPC1RAB9AGAASMN1; SMN2
SCHEMBL19373095 0.77 GAA (0.45) ALDH1A1RAB9AGAASMN1; SMN2P2RX7
SCHEMBL10243951 0.76 ALDH1A1 (0.47) ALDH1A1NPC1RAB9AGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11124482-B2 C-met modulators and methods of use EXELIXIS, INC. (US) 2021-09-21 — — US disclosed
US-20210253530-A9 C-MET MODULATORS AND METHODS OF USE EXELIXIS, INC. 2021-08-19 — — US disclosed
US-20200331860-A1 C-Met Modulators and Methods of Use EXELIXIS INC (US) 2020-10-22 — — US disclosed
EP-3329918-A2 C-MET MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2018-06-06 — — EP disclosed
US-20170355678-A1 C-Met Modulators and Methods of Use EXELIXIS INC (US) 2017-12-14 — — US disclosed
US-20160185725-A1 c-Met Modulators and Method of Use EXELIXIS, INC. 2016-06-30 — — US disclosed
US-20160185725-A1 c-Met Modulators and Method of Use EXELIXIS, INC. 2016-06-30 — — US disclosed
US-20150376133-A1 C-Met Modulators and Methods of Use EXELIXIS, INC. 2015-12-31 — — US disclosed
US-20150376133-A1 C-Met Modulators and Methods of Use EXELIXIS, INC. 2015-12-31 — — US disclosed
US-9174947-B2 c-Met modulators and methods of use Exelixus, Inc. (US) 2015-11-03 — — US disclosed
US-20090170896-A1 c-Met modulators and methods of use EXELIXIS, INC. (US) 2009-07-02 — — US disclosed
US-20090170896-A1 c-Met modulators and methods of use EXELIXIS, INC. (US) 2009-07-02 — — US disclosed
US-20090105299-A1 c-MET MODULATORS AND METHODS OF USE EXELIXIS, INC (US) 2009-04-23 — — US disclosed
US-20090105299-A1 c-MET MODULATORS AND METHODS OF USE EXELIXIS, INC (US) 2009-04-23 — — US disclosed
US-20070244116-A1 c-MET MODULATORS AND METHOD OF USE EXELIXIS, INC. (US) 2007-10-18 — — US disclosed
US-20070244116-A1 c-MET MODULATORS AND METHOD OF USE EXELIXIS, INC. (US) 2007-10-18 — — US disclosed
US-20070225307-A1 C-MET MODULATORS AND METHOD OF USE EXELIXIS, INC. (US) 2007-09-27 — — US disclosed
US-20070225307-A1 C-MET MODULATORS AND METHOD OF USE EXELIXIS, INC. (US) 2007-09-27 — — US disclosed
US-20070054928-A1 c-Met modulators and methods of use EXELIXIS, INC. (US) 2007-03-08 — — US disclosed
US-20070054928-A1 c-Met modulators and methods of use EXELIXIS, INC. (US) 2007-03-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200331860-A1 C-Met Modulators and Methods of Use FLT4, FLT1, MET ALDH1A1 2072/4885FAAH 4388/4885NPC1 3618/4885
US-20070054928-A1 c-Met modulators and methods of use FLT4, FLT1, MET ALDH1A1 2072/4885FAAH 4388/4885NPC1 3618/4885
US-20150376133-A1 C-Met Modulators and Methods of Use FLT4, FLT1, MET ALDH1A1 2072/4885FAAH 4388/4885NPC1 3618/4885
US-20170355678-A1 C-Met Modulators and Methods of Use FLT4, FLT1, MET ALDH1A1 2072/4885FAAH 4388/4885NPC1 3618/4885
US-20210253530-A9 C-MET MODULATORS AND METHODS OF USE FLT4, FLT1, MET ALDH1A1 2072/4885FAAH 4388/4885NPC1 3618/4885
US-20090170896-A1 c-Met modulators and methods of use FLT4, MET, FLT1 ALDH1A1 2597/4885FAAH 4361/4885NPC1 3278/4885
US-20070225307-A1 C-MET MODULATORS AND METHOD OF USE FLT4, MET, FLT1 ALDH1A1 2578/4885FAAH 4338/4885NPC1 3357/4885
US-20160185725-A1 c-Met Modulators and Method of Use FLT4, MET, FLT1 ALDH1A1 2578/4885FAAH 4338/4885NPC1 3357/4885
US-20070244116-A1 c-MET MODULATORS AND METHOD OF USE FLT4, MET, FLT1 ALDH1A1 2578/4885FAAH 4338/4885NPC1 3357/4885
US-11124482-B2 C-met modulators and methods of use FLT4, FLT1, MET ALDH1A1 2072/4885FAAH 4388/4885NPC1 3618/4885
US-20090105299-A1 c-MET MODULATORS AND METHODS OF USE FLT4, MET, FLT1 ALDH1A1 2597/4885FAAH 4361/4885NPC1 3278/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.