Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 16/20 | 0.48 |
| ▸ | STAT5B | P51692 | 5/20 | 0.48 |
| ▸ | STAT1 | P42224 | 4/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | PTPRS | Q13332 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15207908 | 0.92 | STAT3 (0.57) | STAT3STAT5BSTAT1KEAP1NFE2L2 | |
| SCHEMBL10244419 | 0.89 | KEAP1 (0.42) | STAT3STAT5BSTAT1KEAP1NFE2L2 | |
| SCHEMBL15209282 | 0.89 | STAT3 (0.45) | STAT3STAT5BSTAT1KEAP1NFE2L2 | |
| SCHEMBL10245209 | 0.88 | STAT3 (0.50) | STAT3STAT5BSTAT1KEAP1NFE2L2 | |
| SCHEMBL10243401 | 0.86 | KEAP1 (0.46) | STAT3STAT5BSTAT1KEAP1NFE2L2 | |
| SCHEMBL10246056 | 0.85 | STAT3 (0.56) | STAT3STAT5BSTAT1KEAP1NFE2L2 | |
| SCHEMBL10243297 | 0.83 | STAT3 (0.60) | STAT3STAT5BSTAT1 | |
| SCHEMBL10243998 | 0.83 | STAT3 (0.57) | STAT3STAT5BSTAT1KEAP1NFE2L2 | |
| SCHEMBL10246148 | 0.82 | STAT3 (0.66) | STAT3STAT5BSTAT1PTPN2PTPN1 | |
| SCHEMBL10246434 | 0.81 | STAT3 (0.56) | STAT3STAT5BSTAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018868-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEINS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-02-09 | — | — | WO | disclosed |