Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1024480 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TRPV1MEN1KMT2ARAB9A | |
| SCHEMBL1024999 | 0.90 | ALDH1A1 (0.65) | ALDH1A1TRPV1MEN1KMT2ARAB9A | |
| SCHEMBL1024998 | 0.90 | ALDH1A1 (0.65) | ALDH1A1TRPV1MEN1KMT2ARAB9A | |
| SCHEMBL1026801 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1026803 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1025733 | 0.83 | ALDH1A1 (0.59) | ALDH1A1RAB9ANPC1GAAALOX15 | |
| SCHEMBL1072370 | 0.81 | ALDH1A1 (0.79) | ALDH1A1TRPV1MEN1KMT2ARAB9A | |
| SCHEMBL1072365 | 0.81 | ALDH1A1 (0.79) | ALDH1A1TRPV1MEN1KMT2ARAB9A | |
| SCHEMBL1026805 | 0.81 | MEN1 (0.47) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1026804 | 0.81 | MEN1 (0.47) | ALDH1A1MEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |