Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026805 | 1.00 | MEN1 (0.47) | MEN1KMT2AKDM4ERORCALDH1A1 | |
| SCHEMBL1026107 | 0.83 | NR3C1 (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1026801 | 0.83 | ALDH1A1 (0.49) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1026803 | 0.83 | ALDH1A1 (0.49) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1027384 | 0.82 | ALDH1A1 (0.65) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL1027383 | 0.82 | ALDH1A1 (0.65) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL1024998 | 0.82 | ALDH1A1 (0.65) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1024999 | 0.82 | ALDH1A1 (0.65) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1024481 | 0.81 | ALDH1A1 (0.65) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1024480 | 0.81 | ALDH1A1 (0.65) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |