Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 13/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.60 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20893167 | 0.90 | SIRT1 (0.88) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL1302286 | 0.90 | SIRT1 (1.00) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2624433 | 0.88 | SIRT1 (0.85) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL14654576 | 0.88 | SIRT1 (0.84) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740381 | 0.85 | SIRT1 (0.80) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2624781 | 0.84 | SIRT1 (1.00) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740426 | 0.84 | SIRT1 (1.00) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740431 | 0.83 | SIRT1 (0.82) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2624783 | 0.83 | SIRT1 (1.00) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2624513 | 0.83 | SIRT1 (0.87) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9855235-B2 | Compositions and methods for modulating metabolic pathways | NUSIRT SCIENCES, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20170312240-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | NUMETA SCIENCES, INC. | 2017-11-02 | — | — | US | disclosed |
| US-9682053-B2 | Compositions and methods for modulating metabolic pathways | NUSIRT SCIENCES, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160338983-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | NUMETA SCIENCES, INC. | 2016-11-24 | — | — | US | disclosed |
| US-9351967-B2 | Compositions and methods for modulating metabolic pathways | NUSIRT SCIENCES, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160113915-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | NUMETA SCIENCES, INC. | 2016-04-28 | — | — | US | disclosed |
| US-20150342914-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | NUMETA SCIENCES, INC. | 2015-12-03 | — | — | US | disclosed |
| US-9198883-B1 | Compositions and methods for modulating metabolic pathways | NUSIRT SCIENCES, INC. (US) | 2015-12-01 | — | — | US | disclosed |
| US-9072692-B2 | Compositions and methods for modulating metabolic pathways | NUSIRT SCIENCES, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140148488-A1 | Compositions and Methods for Modulating Metabolic Pathways | NUSIRT SCIENCES, INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-8623924-B2 | Compositions and methods for modulating metabolic pathways | NUSIRT SCIENCES, INC. (US) | 2014-01-07 | — | — | US | disclosed |
| US-20130017283-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | NUSIRT SCIENCES, INC. | 2013-01-17 | — | — | US | disclosed |
| US-20130017284-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | NUSIRT SCIENCES, INC. | 2013-01-17 | — | — | US | disclosed |
| US-8163908-B2 | Sirtuin modulating compounds | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20120022254-A1 | SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148488-A1 | Compositions and Methods for Modulating Metabolic Pathways | PC, HADHB, ACACB | SIRT1 5/4885CHRM2 4362/4885ADRA2A 3163/4885 |
| US-20160113915-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | PC, HADHB, ACACB | SIRT1 5/4885CHRM2 4362/4885ADRA2A 3163/4885 |
| US-20130017283-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | PC, HADHB, ACACB | SIRT1 5/4885CHRM2 4362/4885ADRA2A 3163/4885 |
| US-20130017284-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | PC, HADHB, ACACB | SIRT1 5/4885CHRM2 4362/4885ADRA2A 3163/4885 |
| US-20150342914-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | PC, HADHB, ACACB | SIRT1 5/4885CHRM2 4362/4885ADRA2A 3163/4885 |
| US-20120022254-A1 | SIRTUIN MODULATING COMPOUNDS | SIRT1, SIRT3, SIRT2 | SIRT1 1/4885CHRM2 4269/4885ADRA2A 3932/4885 |
| US-20170312240-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | PC, HADHB, ACACB | SIRT1 5/4885CHRM2 4362/4885ADRA2A 3163/4885 |
| US-20160338983-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | PC, HADHB, ACACB | SIRT1 5/4885CHRM2 4362/4885ADRA2A 3163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.