Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 18/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878272 | 0.91 | GPR84 (0.59) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL15094485 | 0.88 | GPR84 (0.51) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL883776 | 0.82 | GPR84 (0.49) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL878500 | 0.82 | GPR84 (0.57) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL878236 | 0.81 | GPR84 (0.49) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL883538 | 0.81 | GPR84 (0.61) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL877616 | 0.79 | GPR84 (0.50) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL878245 | 0.79 | GPR84 (0.49) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL878266 | 0.79 | GPR84 (0.55) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL16188317 | 0.78 | GPR84 (0.59) | GPR84KDM4EALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037782-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | GLAXO GROUP LIMITED (GB) | 2012-03-29 | — | — | WO | disclosed |