Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 17/20 | 0.59 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877876 | 0.91 | GPR84 (0.58) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL878272 | 0.87 | GPR84 (0.59) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL878500 | 0.86 | GPR84 (0.57) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL878380 | 0.85 | GPR84 (0.59) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL878313 | 0.81 | GPR84 (0.47) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL10246108 | 0.80 | GPR84 (0.59) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL10243371 | 0.79 | GPR84 (0.61) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL10246324 | 0.78 | GPR84 (0.54) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL883776 | 0.78 | GPR84 (0.49) | GPR84PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL877192 | 0.78 | GPR84 (0.49) | GPR84PDE4AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871928-B2 | Tricyclic compounds, preparation methods, and their uses | GLAXO GROUP LIMITED (GB) | 2014-10-28 | — | — | US | claimed |