Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.70 |
| ▸ | SCN1A | P35498 | 3/20 | 0.70 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.70 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.70 |
| ▸ | TSHR | P16473 | 7/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12392710 | 0.91 | CYP1A2 (0.60) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| SCHEMBL22987103 | 0.91 | CYP1A2 (0.78) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| SCHEMBL14304169 | 0.89 | CYP1A2 (0.72) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| Ambucaine SCHEMBL82280 | 0.88 | SCN1A (0.91) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| SCHEMBL15295021 | 0.88 | CYP1A2 (0.59) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| SCHEMBL7734044 | 0.88 | TSHR (0.65) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| Ambucaine SCHEMBL1007224 | 0.87 | CYP2D6 (0.88) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| SCHEMBL5925544 | 0.87 | CYP1A2 (0.72) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| SCHEMBL11109738 | 0.86 | ALDH1A1 (0.68) | CYP1A2CYP2D6SCN1ASCN2ASCN3A | |
| SCHEMBL14577737 | 0.85 | TSHR (0.60) | CYP1A2CYP2D6SCN1ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-13 | — | — | US | disclosed |
| WO-2015179956-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2015-12-03 | — | — | WO | disclosed |
| US-20150038708-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-05 | — | — | US | disclosed |
| US-8846707-B2 | Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of stat protein | UNIVERISTY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| WO-2012018868-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEINS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038708-A1 | SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN | STAT3, STAT1, STAT4 | CYP1A2 4214/4885CYP2D6 4083/4885SCN1A 3264/4885 |
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | STAT5A, STAT5B, JAK2 | CYP1A2 4466/4885CYP2D6 3670/4885SCN1A 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.