Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 2/20 | 0.30 |
| ▸ | CHUK | O15111 | 2/20 | 0.30 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | CDK11B | P21127 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.30 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.30 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829552 | 0.72 | CDK2 (0.33) | CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL14012581 | 0.71 | CDK2 (0.32) | CDK2CCNE2CCNE1CDK1 | |
| Hydrochloric Acid SCHEMBL3710324 | 0.67 | CDK2 (0.45) | CDK2CCNE2CCNE1CDK1CDK7 | |
| SCHEMBL13268635 | 0.66 | MEN1 (0.41) | CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL1979674 | 0.63 | CDK2 (0.45) | CDK2CCNE2CCNE1CDK1CDK7 | |
| SCHEMBL17801609 | 0.63 | CDK2 (0.34) | CDK2 | |
| SCHEMBL17342209 | 0.63 | RAB9A (0.43) | PRKCIPRKD3PRKD1 | |
| SCHEMBL12851783 | 0.62 | CDK2 (0.36) | CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL12851685 | 0.62 | MAPK1 (0.34) | CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL13188146 | 0.62 | CDK2 (0.41) | CDK2CCNE2CCNE1CDK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101611-B2 | Substituted pyridazines inhibitors of MEK | ARRAY BIOPHARMA INC. (US) | 2012-01-24 | — | — | US | disclosed |