Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL993758 | 0.82 | NR1H2 (0.43) | USP2SMN1; SMN2PREPMEN1KMT2A | |
| SCHEMBL222920 | 0.77 | PREP (0.53) | USP2SMN1; SMN2PREPMEN1KMT2A | |
| SCHEMBL1488353 | 0.73 | USP2 (0.48) | USP2SMN1; SMN2MEN1KMT2AESR2 | |
| SCHEMBL8478755 | 0.73 | USP2 (0.48) | USP2SMN1; SMN2MEN1KMT2AESR2 | |
| SCHEMBL30793490 | 0.73 | NR1H2 (0.47) | USP2SMN1; SMN2PREPMEN1KMT2A | |
| SCHEMBL994715 | 0.72 | PREP (0.32) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| SCHEMBL1257642 | 0.71 | USP2 (0.43) | USP2SMN1; SMN2MEN1KMT2AESR2 | |
| SCHEMBL16360068 | 0.71 | ESR2 (0.46) | USP2SMN1; SMN2MEN1KMT2AESR2 | |
| SCHEMBL30487365 | 0.71 | ESR2 (0.46) | SMN1; SMN2MEN1KMT2AESR2NR1H2 | |
| SCHEMBL21876055 | 0.70 | USP2 (0.50) | USP2SMN1; SMN2MEN1KMT2AESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241833-A1 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILISATION | Cerenis Therapeutics Holding SA (FR) | 2017-11-08 | — | — | EP | disclosed |