Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026524 | 0.82 | CHRNB2 (0.53) | CHRNB2CHRNA4PDE7AALDH1A1MEN1 | |
| SCHEMBL15498199 | 0.79 | CHRNB2 (0.73) | CHRNB2CHRNA4ALDH1A1MEN1KMT2A | |
| SCHEMBL7295306 | 0.77 | NPC1 (0.57) | ALDH1A1MEN1KMT2AMAPTLTA4H | |
| SCHEMBL7873589 | 0.76 | CHRNB2 (0.66) | CHRNB2CHRNA4ALDH1A1MEN1KMT2A | |
| SCHEMBL14028449 | 0.76 | CHRNB2 (0.69) | CHRNB2CHRNA4ALDH1A1MEN1KMT2A | |
| SCHEMBL30527922 | 0.75 | MEN1 (0.52) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL3977089 | 0.75 | CHRNB2 (0.64) | CHRNB2CHRNA4ALDH1A1MEN1KMT2A | |
| SCHEMBL8901225 | 0.75 | CHRNB2 (0.64) | CHRNB2CHRNA4ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5405414 | 0.75 | CHRNB2 (0.64) | CHRNB2CHRNA4ALDH1A1MEN1KMT2A | |
| SCHEMBL1025102 | 0.74 | MEN1 (0.55) | CHRNB2CHRNA4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |