Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15498199 | 0.79 | CHRNB2 (0.73) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL3977089 | 0.78 | CHRNB2 (0.64) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1027626 | 0.76 | MEN1 (0.57) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1027628 | 0.76 | MEN1 (0.57) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL14028449 | 0.76 | CHRNB2 (0.69) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL6057213 | 0.75 | CHRNB2 (0.61) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1025101 | 0.74 | CHRNB2 (0.53) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL11257936 | 0.74 | CHRNB2 (0.59) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL12672914 | 0.74 | MEN1 (0.57) | MEN1KMT2AALDH1A1THRBHPGD | |
| Hydrochloric Acid SCHEMBL8053891 | 0.74 | DRD2 (0.75) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |