Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 12/20 | 0.44 |
| ▸ | TLR1 | Q15399 | 12/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470147 | 0.88 | HRH3 (0.46) | HRH3SIGMAR1 | |
| SCHEMBL2471160 | 0.88 | CHRM5 (0.47) | HRH3SIGMAR1 | |
| SCHEMBL10252725 | 0.88 | CHRM5 (0.47) | HRH3SIGMAR1 | |
| SCHEMBL2471588 | 0.83 | ALDH1A1 (0.55) | HRH3SIGMAR1 | |
| SCHEMBL2467207 | 0.82 | CHRM5 (0.68) | HRH3 | |
| SCHEMBL10253940 | 0.82 | HTT (0.46) | — | |
| SCHEMBL2465508 | 0.80 | KCNH2 (0.54) | HRH3SIGMAR1 | |
| SCHEMBL2700951 | 0.79 | SIGMAR1 (0.59) | HRH3SIGMAR1 | |
| SCHEMBL13182883 | 0.79 | HRH3 (0.41) | HRH3SIGMAR1 | |
| SCHEMBL2467926 | 0.79 | GRIN2B (0.51) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501467-B1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |