Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025315 | 1.00 | OPRK1 (0.43) | OPRK1OPRM1KCNH2POLBS1PR4 | |
| SCHEMBL1022406 | 0.94 | OPRM1 (0.45) | OPRK1OPRM1KCNH2POLBS1PR4 | |
| SCHEMBL1022409 | 0.94 | OPRM1 (0.45) | OPRK1OPRM1KCNH2POLBS1PR4 | |
| SCHEMBL1022408 | 0.94 | OPRM1 (0.45) | OPRK1OPRM1KCNH2POLBS1PR4 | |
| SCHEMBL4114703 | 0.89 | OPRK1 (0.48) | OPRK1OPRM1KCNH2SLC6A2SLC6A3 | |
| SCHEMBL4114710 | 0.89 | OPRK1 (0.48) | OPRK1OPRM1KCNH2SLC6A2SLC6A3 | |
| SCHEMBL4114706 | 0.89 | OPRK1 (0.48) | OPRK1OPRM1KCNH2SLC6A2SLC6A3 | |
| SCHEMBL1025316 | 0.87 | OPRK1 (0.38) | OPRK1OPRM1KCNH2POLBS1PR4 | |
| SCHEMBL1021553 | 0.80 | POLB (0.53) | OPRK1OPRM1KCNH2POLBS1PR4 | |
| SCHEMBL1021554 | 0.80 | POLB (0.53) | OPRK1OPRM1KCNH2POLBS1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987006-B1 | NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI AVENTIS (FR) | 2011-01-12 | — | — | EP | disclosed |