Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.42 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.42 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497408 | 0.91 | CHRM5 (0.51) | CHRM5CHRM3KMT2AMEN1RAB9A | |
| SCHEMBL10254743 | 0.89 | CHRM5 (0.54) | CHRM5CHRM3KMT2ARAB9AOPRL1 | |
| SCHEMBL10253404 | 0.86 | OPRL1 (0.55) | CHRM5CHRM3KMT2ARAB9AOPRL1 | |
| SCHEMBL10253999 | 0.85 | OPRL1 (0.56) | CHRM5CHRM3KMT2AMEN1RAB9A | |
| SCHEMBL14327377 | 0.83 | PLAAT3 (0.48) | CHRM5CHRM3KMT2AMEN1OPRL1 | |
| SCHEMBL2470375 | 0.82 | CHRM5 (0.49) | CHRM5CHRM3KMT2AMEN1OPRL1 | |
| SCHEMBL2472379 | 0.80 | CHRM5 (0.55) | CHRM5CHRM3KMT2AMEN1 | |
| SCHEMBL378864 | 0.79 | CHRM5 (0.57) | CHRM5CHRM3KMT2AMEN1RAB9A | |
| SCHEMBL10260225 | 0.79 | OPRL1 (0.50) | CHRM5CHRM3KMT2AOPRL1SMN1; SMN2 | |
| SCHEMBL2471734 | 0.78 | EPHX2 (0.53) | CHRM5CHRM3KMT2AMEN1PLAAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501467-B1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |