Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.45 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.45 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471734 | 0.85 | EPHX2 (0.53) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2472649 | 0.83 | CHRM5 (0.52) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2517627 | 0.83 | CHRM5 (0.54) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2468618 | 0.83 | CHRM5 (0.54) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2471543 | 0.82 | PLAAT3 (0.49) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2471846 | 0.81 | CHRM5 (0.50) | CHRM5CHRM3KMT2AMEN1EPHX2 | |
| SCHEMBL2469451 | 0.81 | PLAAT3 (0.49) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL378386 | 0.81 | TACR1 (0.57) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2473234 | 0.81 | CHRM5 (0.70) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL14327377 | 0.81 | PLAAT3 (0.48) | CHRM5CHRM3KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408745-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010106081-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-23 | — | — | WO | disclosed |