SCHEMBL10258116

SCHEMBL10258116

CCOC(=O)CCN(Cc1ccc(OC)cc1)CC(CC)c1ccc(F)cc1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.43
FFAR1 O14842 2/20 0.41
KLK7 P49862 2/20 0.39
TAS2R14 Q9NYV8 1/20 0.39
CETP P11597 1/20 0.38
KMT2A Q03164 2/20 0.38
NR1H3 Q13133 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
MEN1 O00255 1/20 0.37
TP53 P04637 1/20 0.37
MAPT P10636 1/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12685636 0.90 HPGD (0.41) HPGDALOX15FFAR1KLK7TAS2R14
SCHEMBL10258588 0.90 TDP1 (0.48) HPGDALOX15FFAR1TAS2R14NR1H3
SCHEMBL362318 0.88 HPGD (0.44) HPGDALOX15FFAR1KLK7TAS2R14
SCHEMBL12685520 0.80 TDP1 (0.45) HPGDALOX15NR1H3TDP1LMNA
SCHEMBL10258186 0.78 SMN1; SMN2 (0.41) HPGDALOX15KMT2ASMN1; SMN2LMNA
SCHEMBL10258037 0.78 HPGD (0.44) HPGDALOX15FFAR1KLK7TAS2R14
SCHEMBL9833066 0.78 ALDH1A1 (0.48) ALOX15KMT2ASMN1; SMN2LMNAGAA
SCHEMBL513687 0.77 TDP1 (0.48) HPGDALOX15TAS2R14NR1H3TDP1
SCHEMBL513806 0.76 TP53 (0.44) HPGDALOX15FFAR1KLK7TAS2R14
SCHEMBL25489028 0.76 LTA4H (0.46) ALOX15KMT2ASMN1; SMN2LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150336975-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2015-11-26 US disclosed
US-20150152089-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL MYERS SQUIBB CO (US) 2015-06-04 US disclosed
US-8710061-B2 Compounds for the reduction of β-amyloid production BRISTOL-MYERS SQUIBB COMPANY (US) 2014-04-29 US disclosed
US-8637525-B2 Compounds for the reduction of beta-amyloid production BRISTOL-MYERS SQUIBB COMPANY (US) 2014-01-28 US disclosed
US-8486952-B2 Compounds for the reduction of β-amyloid production BRISTOL-MYERS SQUIBB COMPANY (US) 2013-07-16 US disclosed
US-20130178462-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2013-07-11 US disclosed
US-20130030011-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY 2013-01-31 US disclosed
US-20120028994-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY 2012-02-02 US disclosed
US-20110212937-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY 2011-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212937-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP HPGD 586/4885ALOX15 1050/4885FFAR1 2361/4885
US-20150152089-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP HPGD 586/4885ALOX15 1050/4885FFAR1 2361/4885
US-20120028994-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP HPGD 586/4885ALOX15 1050/4885FFAR1 2361/4885
US-20130178462-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP HPGD 586/4885ALOX15 1050/4885FFAR1 2361/4885
US-20150336975-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP HPGD 586/4885ALOX15 1050/4885FFAR1 2361/4885
US-20130030011-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP HPGD 586/4885ALOX15 1050/4885FFAR1 2361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.