Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 13/20 | 0.61 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | DRD5 | P21918 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675116 | 0.89 | HTR1F (0.48) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL13675124 | 0.87 | HTR1F (0.46) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL10267342 | 0.83 | HTR1F (0.53) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL1198119 | 0.82 | HTR1F (0.64) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL10259696 | 0.82 | HTR1F (0.55) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL30908910 | 0.82 | HTR1F (0.77) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL2537931 | 0.82 | HTR1F (0.77) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| Hydrochloric Acid SCHEMBL2539518 | 0.81 | HTR1F (0.76) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL4517381 | 0.81 | HTR1F (0.55) | HTR1FHTR1DHTR1AHTR1BHTR2A | |
| SCHEMBL13675117 | 0.81 | NPC1 (0.46) | HTR1FHTR1DCHRM5DRD5HTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626958-B1 | (PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT 1F AGONISTS | LILLY CO ELI (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |