Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 8/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 10/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10260101 | 0.89 | HTR1F (0.61) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL12020972 | 0.83 | HTR1F (0.51) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL4496011 | 0.83 | WDR5 (0.46) | HTR1FWDR5HTR1AHTR1B | |
| SCHEMBL30908924 | 0.83 | HTR1F (0.70) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL2539234 | 0.83 | HTR1F (0.70) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL13675124 | 0.82 | HTR1F (0.46) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| Hydrochloric Acid SCHEMBL2537296 | 0.82 | HTR1F (0.68) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL4515858 | 0.82 | HTR1F (0.46) | HTR1FHTR1DWDR5HTR1AHTR1B | |
| SCHEMBL12878407 | 0.81 | HTR1F (0.48) | HTR1FHTR1DCHRM5DRD5HTR1E | |
| SCHEMBL4509643 | 0.81 | HTR1F (0.48) | HTR1FHTR1DCHRM5DRD5HTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |