Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 8/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4508907 | 0.99 | HTR1F (0.55) | HTR1FACKR3HPGDWDR5AVPR2 | |
| Hydrochloric Acid SCHEMBL4508902 | 0.98 | HTR1F (0.57) | HTR1FACKR3HPGDWDR5AVPR2 | |
| SCHEMBL4508139 | 0.90 | HTR1F (0.53) | HTR1FACKR3AVPR2RAB9AMAPT | |
| SCHEMBL4510234 | 0.89 | HTR1F (0.55) | HTR1FACKR3HPGDWDR5AVPR2 | |
| SCHEMBL4515254 | 0.88 | KCNK3 (0.50) | ACKR3RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL4515858 | 0.86 | HTR1F (0.46) | HTR1FACKR3WDR5ALDH1A1HTR1A | |
| SCHEMBL10258669 | 0.84 | HTR1F (0.66) | HTR1FHTR1AHTR1DHTR1B | |
| SCHEMBL4515354 | 0.84 | HTR1F (0.44) | HTR1FACKR3MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL4494274 | 0.83 | HTR1F (0.65) | HTR1FHTR1AHTR1DHTR1B | |
| SCHEMBL4506117 | 0.83 | TYK2 (0.48) | HTR1FMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626958-B1 | (PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT 1F AGONISTS | LILLY CO ELI (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |