Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 17/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 8/20 | 0.54 |
| ▸ | HTR1D | P28221 | 6/20 | 0.54 |
| ▸ | HTR1B | P28222 | 5/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | UBE2M | P61081 | 1/20 | 0.51 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4494274 | 0.99 | HTR1F (0.65) | HTR1FMEN1KMT2AHTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL4494266 | 0.98 | HTR1F (0.64) | HTR1FMEN1KMT2AHTR1AHTR1D | |
| SCHEMBL4507335 | 0.89 | HTR1F (0.53) | HTR1FMEN1KMT2AHTR1AHTR1D | |
| SCHEMBL4495882 | 0.87 | KCNK3 (0.51) | HTR1FMEN1KMT2AHTR1AHTR1D | |
| SCHEMBL4508139 | 0.86 | HTR1F (0.53) | HTR1FHTR1AHTR1DHTR1BUBE2M | |
| SCHEMBL4510216 | 0.86 | HTR1F (0.53) | HTR1FHTR1AHTR1DHTR1BUBE2M | |
| SCHEMBL10259591 | 0.85 | RAB9A (0.48) | HTR1FHTR1D | |
| Hydrochloric Acid SCHEMBL4509020 | 0.84 | RAB9A (0.47) | HTR1FHTR1D | |
| SCHEMBL10260508 | 0.84 | HTR1F (0.56) | HTR1FHTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL4509012 | 0.83 | RAB9A (0.46) | HTR1FHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626958-B1 | (PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT 1F AGONISTS | LILLY CO ELI (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |