Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545312 | 0.87 | KDR (0.55) | AXLFGFR1KDRBRAFMET | |
| SCHEMBL10262734 | 0.87 | P2RX3 (0.44) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL10263998 | 0.86 | KDR (0.55) | KDRBRAF | |
| SCHEMBL545443 | 0.81 | KDR (0.53) | AXLFGFR1KDRBRAFMET | |
| SCHEMBL545450 | 0.79 | BRAF (0.50) | FGFR1KDRBRAFHDAC3HDAC8 | |
| SCHEMBL10268161 | 0.76 | BRAF (0.42) | KDRBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL545989 | 0.74 | KDR (0.58) | AXLFGFR1KDRBRAFMET | |
| SCHEMBL5418532 | 0.74 | RAF1 (0.55) | AXLFGFR1KDRBRAFMET | |
| SCHEMBL546771 | 0.73 | BRAF (0.57) | AXLFGFR1KDRBRAFMET | |
| SCHEMBL545949 | 0.73 | KDR (0.74) | KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |