Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | CDK9 | P50750 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858276 | 0.86 | BRD4 (0.62) | CDC7BRD4FGFR1FGFR4DYRK1A | |
| SCHEMBL5429312 | 0.84 | BRD4 (0.55) | CDC7BRD4FGFR1FGFR4DYRK1A | |
| SCHEMBL16719412 | 0.81 | CDC7 (0.50) | CDC7BRD4FGFR1FGFR4DYRK1A | |
| SCHEMBL26176389 | 0.80 | BRD4 (0.64) | CDC7BRD4DYRK1AGSK3BCDK2 | |
| SCHEMBL3331546 | 0.80 | DYRK1A (0.62) | CDC7BRD4FGFR1FGFR4DYRK1A | |
| SCHEMBL31711042 | 0.80 | LRRK2 (0.55) | CDC7BRD4FGFR1FGFR4DYRK1A | |
| SCHEMBL857087 | 0.80 | CDC7 (0.64) | CDC7BRD4FGFR1FGFR4DYRK1A | |
| SCHEMBL857148 | 0.78 | TGFBR1 (0.57) | CDC7DYRK1AGSK3BCDK2CDK9 | |
| SCHEMBL5618155 | 0.77 | TGFBR1 (0.71) | CDC7BRD4DYRK1AGSK3BCDK2 | |
| SCHEMBL16719977 | 0.76 | BRD4 (0.53) | CDC7BRD4FGFR1FGFR4DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022098-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2012-01-26 | — | — | US | disclosed |
| US-20120022098-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022098-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | CDC7 161/4885BRD4 727/4885FGFR1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.