Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.71 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.71 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.71 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.65 |
| ▸ | AXL | P30530 | 1/20 | 0.64 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.62 |
| ▸ | CDC7 | O00311 | 4/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.62 |
| ▸ | PIM1 | P11309 | 3/20 | 0.62 |
| ▸ | PRKACA | P17612 | 3/20 | 0.62 |
| ▸ | GSK3B | P49841 | 3/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.62 |
| ▸ | CDK9 | P50750 | 3/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.62 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050911 | 0.90 | TGFBR1 (0.60) | TGFBR1IKBKEPDPK1TBK1AXL | |
| SCHEMBL12501089 | 0.87 | TGFBR1 (0.63) | TGFBR1IKBKEPDPK1TBK1AXL | |
| SCHEMBL26174482 | 0.87 | DYRK1B (0.63) | TGFBR1IKBKEPDPK1TBK1AXL | |
| SCHEMBL16719379 | 0.86 | TGFBR1 (0.57) | TGFBR1IKBKEPDPK1TBK1AXL | |
| SCHEMBL3740263 | 0.86 | CAMKK2 (0.69) | TGFBR1IKBKEPDPK1AXLCDC7 | |
| SCHEMBL15397129 | 0.86 | IKBKE (0.78) | TGFBR1IKBKEPDPK1TBK1AXL | |
| SCHEMBL20846162 | 0.86 | AXL (0.64) | TGFBR1IKBKEPDPK1TBK1AXL | |
| SCHEMBL20846051 | 0.86 | RPS6KA5 (0.58) | TGFBR1IKBKEPDPK1TBK1AXL | |
| SCHEMBL20846288 | 0.86 | CAMKK2 (0.60) | TGFBR1IKBKEPDPK1TBK1AXL | |
| SCHEMBL858410 | 0.86 | TGFBR1 (0.57) | TGFBR1IKBKEPDPK1TBK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050267304-A1 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2005-12-01 | — | — | US | claimed |
| US-7227020-B2 | Azaindoles | AVENTIS PHARMA LIMITED (GB) | 2007-06-05 | — | — | US | disclosed |
| US-20040198737-A1 | Azaindoles | AVENTIS PHARMA LIMITED (GB) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198737-A1 | Azaindoles | CCNY, CCNO, CNKSR1 | TGFBR1 3736/4885IKBKE 1390/4885PDPK1 1003/4885 |
| US-20050267304-A1 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | MAP3K20, MAP3K12, MAP3K19 | TGFBR1 2066/4885IKBKE 120/4885PDPK1 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.