Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 5/20 | 0.59 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.53 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10263343 | 0.82 | ENPP3 (0.84) | ENPP3SCN9AENPP1KMT2AKDM4E | |
| SCHEMBL14564372 | 0.81 | ENPP3 (0.71) | ENPP3SCN9AENPP1KMT2AMEN1 | |
| SCHEMBL9954331 | 0.79 | KDM4E (0.50) | KMT2AKDM4EMEN1MAPTNOTUM | |
| SCHEMBL8418313 | 0.79 | ENPP3 (0.56) | ENPP3SCN9AENPP1KMT2AMEN1 | |
| SCHEMBL3318051 | 0.79 | ENPP3 (0.59) | ENPP3SCN9AENPP1 | |
| SCHEMBL10263341 | 0.79 | ENPP3 (0.59) | ENPP3SCN9AENPP1KMT2AMEN1 | |
| SCHEMBL28702905 | 0.79 | KDM4E (0.46) | KMT2AKDM4EMEN1MAPTNOTUM | |
| SCHEMBL16531906 | 0.79 | ENPP3 (0.59) | ENPP3SCN9AENPP1KMT2AMEN1 | |
| SCHEMBL12021956 | 0.79 | ENPP3 (0.59) | ENPP3SCN9AENPP1KMT2AKDM4E | |
| SCHEMBL6986241 | 0.78 | ENPP3 (0.69) | ENPP3SCN9AENPP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |