Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.39 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545887 | 0.87 | KDR (0.51) | FDPSKDRFLT1KITBRAF | |
| SCHEMBL10262752 | 0.86 | KMT2A (0.39) | FDPSKDRFLT1KITBRAF | |
| SCHEMBL10268162 | 0.86 | KDR (0.43) | KDRFLT1 | |
| SCHEMBL10199733 | 0.81 | KDR (0.42) | FDPSKDRFLT1BRAFKMT2A | |
| SCHEMBL10199956 | 0.81 | RAF1 (0.49) | KDRFLT1BRAFKMT2AMEN1 | |
| SCHEMBL545637 | 0.81 | KDR (0.52) | KDRFLT1KITBRAFKMT2A | |
| SCHEMBL5431873 | 0.81 | BRAF (0.46) | KDRFLT1KITBRAF | |
| SCHEMBL5416351 | 0.81 | RAF1 (0.45) | KDRFLT1BRAF | |
| SCHEMBL545439 | 0.80 | MAPK14 (0.44) | KDRFLT1BRAF | |
| SCHEMBL545010 | 0.79 | KDR (0.50) | KDRFLT1KITBRAFKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |