Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | UBE2N | P61088 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10199733 | 0.87 | KDR (0.42) | KMT2APOLBUBE2NKDM4ETDP1 | |
| SCHEMBL10263298 | 0.86 | FDPS (0.46) | KMT2APOLBUBE2NKDM4ETDP1 | |
| SCHEMBL10268162 | 0.82 | KDR (0.43) | KDRFLT1 | |
| SCHEMBL5416351 | 0.82 | RAF1 (0.45) | BRAFKDRFLT1 | |
| SCHEMBL545439 | 0.81 | MAPK14 (0.44) | BRAFKDRFLT1 | |
| SCHEMBL545637 | 0.81 | KDR (0.52) | KMT2ABRAFKITMEN1HDAC3 | |
| SCHEMBL10199956 | 0.81 | RAF1 (0.49) | KMT2ABRAFMEN1MAPTKDR | |
| SCHEMBL545887 | 0.80 | KDR (0.51) | KMT2AFDPSBRAFKITMEN1 | |
| SCHEMBL545010 | 0.79 | KDR (0.50) | KMT2APOLBKDM4ETDP1BRAF | |
| SCHEMBL546229 | 0.79 | MAPK14 (0.50) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |