Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | CTSC | P53634 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 6/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027670 | 0.88 | BCL6 (0.38) | BCL6BTKCTSCMETALK | |
| SCHEMBL1028822 | 0.87 | CTSC (0.39) | BCL6BTKCTSCMETALK | |
| SCHEMBL1028340 | 0.86 | CTSC (0.42) | BCL6BTKCTSCEGFRSTK17B | |
| SCHEMBL1025086 | 0.85 | BCL6 (0.38) | BCL6BTKCTSCMETALK | |
| SCHEMBL1026721 | 0.84 | JAK3 (0.42) | BCL6CTSCJAK1 | |
| SCHEMBL4334815 | 0.84 | EGFR (0.42) | BTKCTSCMETALKEGFR | |
| SCHEMBL13623208 | 0.82 | SYK (0.48) | BCL6BTKMETALKEGFR | |
| SCHEMBL1028227 | 0.81 | MEN1 (0.42) | BTKALKEGFRMAPTJAK1 | |
| SCHEMBL1023285 | 0.80 | ALK (0.40) | BCL6BTKMETALKMAPT | |
| SCHEMBL1026395 | 0.79 | BCL6 (0.40) | BCL6BTKCTSCMETEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |