Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.38 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026953 | 0.91 | GAA (0.47) | ALKMETMAPTBCL6BTK | |
| SCHEMBL1026721 | 0.88 | JAK3 (0.42) | BCL6 | |
| SCHEMBL1026395 | 0.86 | BCL6 (0.40) | METBCL6BTK | |
| SCHEMBL1025116 | 0.85 | MET (0.41) | ALKMETKMT2ABCL6BTK | |
| SCHEMBL1028227 | 0.84 | MEN1 (0.42) | ALKMEN1KMT2AMAPTBTK | |
| SCHEMBL1025086 | 0.84 | BCL6 (0.38) | ALKMETMAPTBCL6BTK | |
| SCHEMBL4334439 | 0.84 | KMT2A (0.46) | ALKMETMEN1KMT2ALMNA | |
| SCHEMBL1027670 | 0.83 | BCL6 (0.38) | ALKMETMAPTBCL6BTK | |
| SCHEMBL1023949 | 0.82 | ALDH1A1 (0.40) | BCL6BTKALDH1A1 | |
| SCHEMBL13623023 | 0.82 | MET (0.49) | ALKANO1METBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |